May-Hegglin anomaly (MHA) is an inherited disorder of blood cells. This condition is diagnosed via microscopic examination of a blood smear and is characterized by three key features: reduced numbers of normal sized platelets in the blood (thrombocytopenia), the presence of large platelets (macrothrombocytes), and abnormal neutrophils containing structures called inclusion bodies. This dog did not demonstrate clinical signs related to platelet abnormalities however, recognizing a congenital cause for macrothrombocytopenia is important because both thrombocytopenia and macrothrombocytosis can be associated with clinically important diseases. In addition, some blood analyzer machines can misinterpret macrothrombocytes as red blood cells, thus further complicating diagnoses. Though usually asymptomatic, humans with May-Hegglin anomaly have been reported to have issues with blood clotting leading to bruising and spontaneous bleeding. The Pug reported with this condition did not show increased incidence of hemorrhage and blood clotting times were normal.

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