Generalized progressive retinal atrophy is an adult-onset inherited eye disease affecting dogs. Generalized progressive retinal atrophy occurs as a result of degeneration of both rod and cone type photoreceptor cells of the retina, important for vision in dim light and daylight, respectively. Initial clinical signs of progressive retinal atrophy involve changes in reflectivity and appearance of a structure behind the retina called the tapetum that can be observed on a veterinary eye exam. Affected dogs initially present between 2 and 5 years of age with vision loss in dim light (night blindness) and loss of peripheral vision, gradually progressing to complete vision loss. The disease follows a variable progression and severity depending on the individual and complete degeneration of the retina can take up to 2 years.

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