Intestinal cobalamin malabsorption (beagle type) is an inherited disease affecting dogs. Affected dogs are unable to make adequate amounts of a protein that plays a role in absorption of certain nutrients from the intestinal tract and kidneys, including the B vitamin, cobalamin. Affected dogs present as early as 8 to 12 weeks of age with clinical signs including anorexia, lethargy, poor weight gain, poor muscle mass, and in rare circumstances, seizures, coma and death. Affected dogs have an increased methylmalonic acid concentration in the urine (a sign of cobalamin deficiency) as well as an increase in certain urine proteins. In addition, affected dogs frequently display anemia, decreased numbers of neutrophils, and have been reported to develop degenerative liver disease and free fluid in the abdomen. Affected dogs require cobalamin supplementation for life that results in disease remission for most animals within a few weeks. Though not associated with medical problems, affected dogs will continue to pass increased amounts of certain proteins in the urine even with cobalamin supplementation.

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