Myostatin deficiency is an inherited condition of muscles affecting dogs. Affected dogs are unable to produce adequate amounts of a protein known as myostatin, which plays an important role in the regulation of muscle mass. Affected dogs have significantly enlarged muscles (“double muscling”) that are prone to cramping; especially in the shoulder and thigh. In addition, about 50% of affected dogs develop an overbite. Dogs inheriting only a single copy of the mutation (carriers) develop an intermediate muscle size that may improve overall physical performance. Dogs inheriting this mutation are not known to develop other health problems as a result and are expected to have a normal lifespan.

Read More