Polyneuropathy (Leonberger and Saint Bernard Type) is an inherited neurologic disease affecting dogs. Affected dogs most commonly present before 3 years of age with signs of generalized neurologic disease including weakness, loss of muscle tone, muscle atrophy, awkward high-stepping gait in the hind limbs, decreased reflexes, abnormal bark sounds and increased breathing sounds due to paralysis of the larynx. With time, the disease may progress to the point that affected dogs are unable to bear weight or walk. Although published reports indicate that this is an autosomal recessive condition in most dogs, meaning that two copies of the mutation are required for a dog to be affected, some dogs with a single copy of the mutation (carriers) may also be at-risk of developing the disease.

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