Other Names: Pseudohemophilia, Vascular hemophilia, von Willebrand's disease, VWDII
Inheritance: Autosomal Recessive
Mutation(s): A>G
Affected Gene(s): VWF
Affected Breed(s): Deutsch Kurzhaar, Deutsch-Drahthaar, German Shorthaired Pointer, German Wirehaired Pointer

Common Symptoms

Von Willebrand disease type II (VWDII) is an inherited bleeding disorder affecting dogs. Dogs affected with VWDII have decreased levels and abnormal function of von Willebrand coagulation factor (vWf), which is an essential protein needed for normal blood clotting. Affected dogs generally have moderate to severe signs of a bleeding disorder. Affected dogs may bruise easily, have frequent nosebleeds, bleed from the mouth when juvenile teeth are lost and experience prolonged bleeding after surgery or trauma. The bleeding may be severe enough to cause death. Due to variable severity of the disorder, affected dogs may not be identified until a surgery is performed or trauma occurs at which time excessive bleeding is noted. Veterinarians performing surgery on known affected dogs should have ready access to blood banked for transfusions. Dogs can have a normal lifespan with this condition although they are susceptible to life-threatening bleeding with an accidental injury or any surgical procedure.

References

  • Gavazza A, Presciuttini S, Keuper H, Lubas G. Estimated prevalence of canine Type 2 Von Willebrand disease in the Deutsch-Drahthaar (German Wirehaired Pointer) in Europe. Res Vet Sci. 2012 Dec;93(3):1462-6. [PubMed: 22824509]
  • Kramer JW, Venta PJ, Klein SR, Cao Y, Schall WD, Yuzbasiyan-Gurkan V. A von Willebrand’s factor genomic nucleotide variant and polymerase chain reaction diagnostic test associated with inheritable type-2 von Willebrand's disease in a line of german shorthaired pointer dogs. Vet Pathol. 2004 May; 41(3):221-8. [PubMed: 15133170]
  • van Dongen AM, van Leeuwen M, Slappendel RJ. Canine von Willebrand's disease type 2 in German wirehair pointers in the Netherlands. Vet Rec. 2001 Jan 20; 148(3):80-2. [PubMed: 12503596]