Cyclic neutropenia is an inherited disease affecting collies. Affected dogs undergo an oscillating cycle in the quantity of a type of white blood cells called neutrophils, important for controlling and preventing bacterial and fungal infections. Affected dogs have neutrophil counts oscillating between normal quantities to almost zero neutrophils on an approximately 2 week frequency. Affected puppies often die within a few days of birth or are stunted in growth. Affected dogs have a gray coat color and are vulnerable to infections during periods of low neutrophil counts. Symptoms associated with this condition are normally seen during or immediately after a period of low neutrophil counts. Symptoms include fever, diarrhea, inflamed lymph nodes, gingivitis, lameness and mild bleeding episodes. Even with medical care, most dogs die before 2 years of age due to liver or kidney failure.

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