Cone degeneration is an inherited eye disease affecting dogs. Affected dogs develop day blindness (blindness in bright light) and photophobia (light sensitivity) between 8 to 12 weeks after birth due to degeneration of cells in the eye called cone photoreceptors which are responsible for vision in bright light. Affected dogs have normal vision in low light and structures of the inner eye appear normal on eye exam. Normal cone cell function can be seen on electroretinogram (ERG) before six weeks of age, but becomes abnormal between 6 to 12 weeks of age and is completely absent in affected adult dogs signifying complete loss of cone cells. The cells responsible for vision in low light called rod photoreceptors are not affected and thus, affected dogs will still be able to see normally in low light throughout life.

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