Fanconi syndrome is an inherited disorder of the kidneys affecting dogs. Affected dogs typically present with clinical signs of abnormal kidney function in adulthood with an average age of onset between four and eight years of age. Normally the kidneys reabsorb most of the nutrients and electrolytes that they filter from the blood. The kidneys of affected dogs do not properly reabsorb nutrients and electrolytes, such as glucose, protein, phosphate, potassium and sodium, and abnormally lose these nutrients in the urine. Symptoms of abnormal kidney function in affected dogs most commonly include increased urination and excessive drinking. Less often dogs may have weight loss despite a normal appetite, weakness, urinary incontinence and poor hair coat. A common characteristic of this disease is glucose in the urine with normal blood glucose levels. Fanconi syndrome is treatable but not curable. If an affected dog is not treated, the disease can progress to chronic kidney failure and overall poor health. Appropriate treatment can preserve the health and quality of life of affected dogs. The median survival time after diagnosis is five years with most dogs dying around 12 years of age. This late age of onset allows for most dogs to be bred before diagnosis and subsequently, the disease is passed to offspring.

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