Complement 3 deficiency is a disorder of the immune system affecting the Brittany that is characterized by a lack of the protein complement component 3. Complement component 3 (C3) plays an important role in preventing bacterial infection. C3 deficiency most commonly affects younger dogs and affected dogs will present with reoccurring bacterial infections, including pneumonia, urinary tract infections and uterine infections. C3 deficiency predisposes affected dogs to kidney disease early in life which can lead to chronic kidney failure and death.

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